Living-Donor Intestinal Transplantation :Past, Present and Future
10.3760/cma.j.cn421203-20230921-00099
- VernacularTitle:活体小肠移植的历史、现状与未来
- Author:
Guosheng WU
1
Author Information
1. 浙江大学医学院附属第一医院结直肠外科小肠移植中心，杭州 310003
- Keywords:
Intestinal transplantation;
Living small intestine transplantation;
Prognosis
- From:
Chinese Journal of Organ Transplantation
2024;45(4):243-250
- CountryChina
- Language:Chinese
-
Abstract:
Intestinal transplantation (ITx) is currently a vital life-saving strategy for patients with irreversible intestinal failure. Living donor intestinal transplantation, procuring segmental intestinal graft usually from healthy close relatives, offers several advantages over deceased donation, including well-planned procedures, shorter ischemic duration, optimized tissue matching and lower rejection rates. Intestinal transplantation has been performed most commonly using deceased donation. Approximately 2% of intestinal transplantation (slightly over 100 cases) was harvested from living donation. Preliminary results indicated that graft and recipient survivals after living donation were superior to those after intestinal transplantation from deceased donation. Mid/long-term recipient survivals were equal to those undergoing home parenteral nutrition (HPN). With richer experiences and greater advances in surgical techniques, living donor intestinal transplantation has been becoming a sole therapeutic choice for chronic intestinal failure and a mere life-saving maneuver in some instances. Better understanding the mechanisms of triggering rejection, exploring a novel non-invasive method for detecting early intestinal damage, further establishing surgical indications for living donor intestinal transplantation and lowering postoperative complications are critical for achieving better long-term outcomes.
