Clinical application of metagenomic next generation sequencing technology for Legionella pneumonia after allogeneic hematopoietic stem cell transplantation: a report of 6 cases

VernacularTitle:宏基因二代测序在异基因造血干细胞移植后军团菌肺炎的6例临床应用观察
Author: Jing XIA ¹ ; Junhong JIANG ; Ye ZHAO ; Xiao MA ; Depei WU ; Suning CHEN ; Feng CHEN
Author Information

1. 苏州大学附属第一医院血液科江苏省血液研究所国家血液系统疾病临床医学研究中心，苏州　215006
Keywords: Hematopoietic stem cell transplantation; Legionnaires pneumonia; Gene sequencing
From: Chinese Journal of Organ Transplantation 2024;45(2):119-121
CountryChina
Language:Chinese
Abstract: This review described the clinical data of 6 recipients with Legionella pneumonia after allogeneic hematopoietic stem cell transplantation (allo-HSCT) through metagenomic next generation sequencing (mNGS) from September 2019 to July 2023 at First Affiliated Hospital of Soochow University. The clinical characteristics and treatment outcomes were retrospectively examined. Legionella infection is a rare opportunistic infection after allo-HSCT. A definite diagnosis is rather difficult and an earlier diagnosis yields a better prognosis. As an early and accurate diagnostic tool for clinical practice, mNGS detection is worthy of wider applications.