The significance of immunological indicators of lymph node for disease free survival of pathological stage Ⅱ colorectal cancer patients by age
10.3760/cma.j.cn113855-20231229-00459
- VernacularTitle:淋巴结相关免疫指标对不同年龄的病理Ⅱ期结直肠癌患者无病生存率的影响
- Author:
Pu CHENG
1
;
Zhaoxu ZHENG
Author Information
1. 国家癌症中心 国家肿瘤临床医学研究中心 中国医学科学院北京协和医学院肿瘤医院结直肠外科，北京 100021
- Keywords:
Colorectal neoplasms;
Lymph nodes;
Disease-free survival;
Forcastong;
Risk factors
- From:
Chinese Journal of General Surgery
2024;39(5):362-366
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the significance of immunological indicators of lymph node for disease free survival of pathological stage Ⅱ colorectal cancer based on two age groups.Methods:Data of clinicopathological characteristics of 813 pathological stage Ⅱ CRC patients undergoing surgery between Jan 2011 and Dec 2017 at Department of Colorectal Surgery, Cancer Hospital, Chinese Academy of Medical Sciences were retrospectively analyzed. Patients were divided into two groups based on age, including < 60 years and ≥ 60 years group. The clinicopathological characteristics especially the immunological indicators of lymph node between the two groups were compared. Then, the univariate and multivariate COX regression analysis were conducted in both groups.Results:Compared to age ≥ 60 years group, body mass index > 24 kg/m 2, the number of patients with adjuvant therapy and with deficient mismatch repair were higher in age < 60 years group, while the rate of comorbidity was less in age < 60 years group, the differences were statistically significant ( χ2=6.615, P=0.037; χ2=35.086, P<0.001; χ2=7.678, P=0.006; χ2=13.905, P<0.001). Meanwhile, patients with age<60 years group had larger lymph nodes and more harvested lymph nodes, the differences were statistically significant ( t=2.149, P=0.032; t=3.892, P<0.001). Sex ( P=0.043), tumor location ( P=0.005) and size of lymph nodes ( P<0.001) were independent risk factors in age<60 years group. Tumor location ( P=0.022)and differentiation (well and moderate vs. poor, P=0.034), pathological T stage ( P=0.041)and clinical lymph node stage ( P=0.036) were independent risk factors in age≥60 years group. Conclusion:The immunological indicators of lymph node could predict the disease free survival of pathological stage Ⅱ colorectal cancer in different age group.
