Small-molecule/biological agents in the treatment of pruritus
- VernacularTitle:治疗瘙痒的小分子/生物制剂药物研究进展
- Author:
Lan GUO
1
;
Hongzhong JIN
Author Information
- Keywords: Pruritus; Biological agents; Signal transduction; Small molecule inhibitors
- From: Chinese Journal of Dermatology 2024;57(5):475-478
- CountryChina
- Language:Chinese
- Abstract: In recent years, great progress has been made in the research on the pathogenesis of pruritus, and many new targeted therapeutic drugs have been developed, mainly including small-molecule drugs or biological agents targeting signal transduction pathways involved in the pathogenesis of pruritus, such as neurokinin-1 receptor, tropomyosin-related kinase A, transient receptor potential vanilloid 1, transient receptor potential melastatin 8 channels, interleukin 31, etc. Some of these drugs have shown good efficacy and safety in the treatment of pruritus in a variety of skin diseases, providing more options for patients with pruritus, especially those who are resistant to traditional drug treatment. This review summarizes research progress in the above small-molecule drugs and biological agents targeting signaling pathways involved in pruritus, in order to provide more options for pruritus treatment.
