Acne vulgaris revisited: from pathogenesis to treatment strategies
- VernacularTitle:寻常痤疮再认识：从发病机制到治疗策略
- Author:
Qiang JU
1
;
Jiaqi LI
Author Information
- Keywords: Acne vulgaris; Insulin‐like growth factor 1; Hair follicular microbiome; Pilosebaceous unit; Pathogenesis; Treatment strategies
- From: Chinese Journal of Dermatology 2024;57(4):289-294
- CountryChina
- Language:Chinese
- Abstract: Acne vulgaris is a chronic inflammatory disease of the pilosebaceous unit. Androgen-induced sebum secretion, hyperkeratosis of the pilosebaceous duct, microbial overgrowth in hair follicles, and inflammatory and immune reactions are closely associated with the pathogenesis of acne. However, the pathogenesis and pathophysiological processes of acne remain unclear. With the progression of scientific research, the conventional understanding of acne has been constantly updated in recent years, while clinical treatment principles underwent several transformations as well. This article aims to review some latest theories on the pathogenesis of acne vulgaris and their implications in prevention and treatment from the perspectives of sex hormone levels, hair follicular microorganisms, hair follicle stem cells and pathogenesis of severe acne, so as to provide new directions and ideas for the prevention and treatment of acne vulgaris.
