Chemical constituents from the n-butanol fraction of Siegesbeckia glabrescens
10.3969/j.issn.1001-1528.2024.11.020
- VernacularTitle:毛梗豨莶正丁醇部位化学成分研究
- Author:
Rong YAN
1
;
Zhong-Wen CHEN
;
Yu-Ke ZHANG
;
Xiao-Lu HUANG
;
Bin LEI
;
Hong-Ting YI
;
Feng LIU
;
Hua LIU
Author Information
1. 江西中医药大学药学院,江西 南昌 330004
- Keywords:
Siegesbeckia glabrescens Makino.;
n-butanol fraction;
chemical constituents;
isolation and identification
- From:
Chinese Traditional Patent Medicine
2024;46(11):3664-3671
- CountryChina
- Language:Chinese
-
Abstract:
AIM To study the chemical constituents from the n-butanol fraction of Siegesbeckiae glabrescens Makino.METHODS The n-butanol fraction from S.glabrescens was isolated and purified by silica gel,ODS and preparative HPLC,then the structures of obtained compounds were identified by physicochemical properties and spectral data.RESULTS Seventeen compounds were isolated and identified as orientalin B(1),ent-2-oxo-15,16,19-trihydroxypimar-8(14)-ene(2),ent-12α,16-epoxy-2β,15α,19-trihydroxypimar-8-ene(3),ent-12α,16-epoxy-2β,15α,19-trihydroxy-pimar-8(14)-ene(4),kirenol(5),benzyl-O-β-D-glucopyranoside(6),hexyl-β-glucopyranoside(7),(Z)-3-hexenyl-β-D-glucopyranoside(8),phenylethyl-O-β-D-glucopyranoside(9),(6R,9S)-3-oxo-α-ionol-β-D-glucopyranoside(10),2-methoxy-4-(2-propenyl)phenyl-β-D-glucoside(11),4-allyl-2,6-dimethoxyphenyl glucoside(12),2-hydroxy-methylphenyl-1-O-β-D-glucopyranoside(13),icarside B2(14),everlastoside D(15),(2S,4R,5S,7S,9S,10R,13S,15R)-2,7,15,16,19-pentahydroxypimar-8(14)-ene(16),and benzyl-β-D-apiofuranosyl-(1″→6′)-β-D-glucopy-ranoside(17).Compound 9 showed weak ABTS radical scavenging capability,and compound 15 had strong DPPH and ABTS radicals scavenging activities.CONCLUSION Compounds 7-9,14-15 are isolated from genus Siegesbeckia for the first time.Compounds 2-4,7-17 are first isolated from this plant.Compound 9 and 15 exhibit antioxidant activities.
