Phenylpropanoids from Brandisia hancei and their antioxidant activities
10.3969/j.issn.1001-1528.2024.08.022
- VernacularTitle:来江藤苯丙素类成分及其抗氧化活性研究
- Author:
Chang-Fen LI
1
;
Bin-Bin LIAO
;
Zong-Xu LIU
;
Hong-Yun WANG
;
Xin-Jian ZHANG
;
Ai-Xue ZUO
Author Information
1. 云南中医药大学中药学院,云南省南药可持续利用重点实验室,云南 昆明 650500
- Keywords:
Brandisia hancei Hook.f.;
phenylpropanoids;
isolation and identification;
cytotoxicities;
antioxidant activities
- From:
Chinese Traditional Patent Medicine
2024;46(8):2623-2630
- CountryChina
- Language:Chinese
-
Abstract:
AIM To study the phenylpropanoids from Brandisia hancei Hook.f.and their antioxidant activities.METHODS The extract from B.hancei was isolated and purified by Rp-C18,MCI,semi-preparative HPLC,silica gel and Sephadex LH-20,then the structures of obtained compounds were identified by physicochemical properties and spectral data.The cytotoxicities was determined by MTT method,and the antioxidant activities were determined by DPPH and ABTS+free radical scavenging methods.RESULTS Fifteen phenylpropanoids were isolated and identified as(+)-pinonesinol(1),(-)-medioresinol(2),(-)-syringaresinol(3),buddlenol D(4),(7R,7'R,7″S,8S,8'S,8″S)-4',5″-dihydroxy-3,5,3',4″-tetramethoxy-7,9':7',9-diepoxy-4,8″-oxy-8,8'-sesquineo-lignan-7″,9″-diol(5),(-)-(7R,7'R,7″R,8S,8'S,8″S)-4',4″-dihydroxy-3,3',3″,5-tetramethoxy-7,9':7',9-diepoxy-4,8″-oxy-8,8'-sesquineolignan-7″,9″-diol(6),hedyotol A(7),dracunculifoside R(8),acteoside(9),isoacteoside(10),arenarioside(11),isomartynoside(12),curcasinlignan B(13),erythro-2,3-bis(4-hydroxy-3-methoxyphenyl)-3-ethoxypropan-l-ol(14),citrusin C(15).Compounds 1-4 and 9-10 had no obvious cytotoxicity to HepG2 hepatoma cells.Compounds 1,3,9,10 and 12 had strong scavenging activities against DPPH radicals.Compounds 1-3,9-10,12 and 14 showed strong scavenging activities against ABTS+radical.CONCLUSION Compounds 1-8 and 12-15 are isolated from genus Brandisia for the first time.The phenylpropanoids from B.hancei show strong antioxidant activities.
