Chemical constituents from the flower buds of Magnolia biondii and their in vitro acetylcholinesterase inhibitory activities
10.3969/j.issn.1001-1528.2024.07.026
- VernacularTitle:望春花花蕾化学成分及其乙酰胆碱酯酶体外抑制活性研究
- Author:
Yan-Gang CAO
1
;
Jian-Chao WANG
;
Meng-Na WANG
;
Yu-Huan HE
;
Hong-Wei LI
;
Zhi-You HAO
;
Xiao-Ke ZHENG
;
Wei-Sheng FENG
Author Information
1. 河南中医药大学药学院,河南省中药开发工程技术研究中心,河南 郑州 450046
- Keywords:
Magnolia biondii Pamp.;
flower buds;
chemical constituents;
isolation and identification;
acetylcholinesterase
- From:
Chinese Traditional Patent Medicine
2024;46(7):2278-2283
- CountryChina
- Language:Chinese
-
Abstract:
AIM To study the chemical constituents from flower buds of Magnolia biondii Pamp.and their in vitro acetylcholinesterase inhibitory activities.METHODS The 50% acetone extract from the flower buds of M.biondii was isolated and purified by Diaion HP-20,Toyopearl HW-40C,ODS and semi-preparative HPLC,then the structures of obtained compounds were identified by physicochemical properties and spectral data.The in vitro acetylcholinesterase inhibitory activities of these compounds were determined according to previous method established by research group.RESULTS Seventeen compounds were isolated and identified as crassifolioside(1),magnoloside B(2),rutin(3),isoquercitrin(4),quercetin(5),northalifoline(6),cordysinin B(7),thymidine(8),indazole(9),dihydrodehydrodiconiferyl alcohol(10),aesculetin(11),C-veratroylglycol(12),3,4-dihydroxyphenylethanol(13),3-methoxy-4-hydroxyphenylethanol(14),3,4-dihydroxybenzoic acid(15),2,4,6-trimethoxyphenol(16),syringic acid(17).CONCLUSION Compounds 1-17 are isolated from this plant for the first time,none of which show acetylcholinesterase inhibitory activities at the concentration of 20 μmol/L.
