Chemical constituents of methanol fraction from Lycii Cortex and their anti-inflammatory activities
10.3969/j.issn.1001-1528.2024.05.020
- VernacularTitle:地骨皮甲醇部位的化学成分及其抗炎活性研究
- Author:
Lu-Lu WANG
1
;
Wei HU
;
Hao LI
;
Ye XU
;
Hang LIU
Author Information
1. 南京大学医学院附属鼓楼医院药学部,江苏 南京 210008
- Keywords:
Lycii Cortex;
methanol fraction;
chemical constituents;
isolation and identification;
anti-inflammatory activities
- From:
Chinese Traditional Patent Medicine
2024;46(5):1540-1545
- CountryChina
- Language:Chinese
-
Abstract:
AIM To study chemical constituents of methanol fraction from Lycii Cortex and their anti-inflammatory activities.METHODS The 70%ethanol extract of Lycii Cortex was isolated and purified by various modern chromatographic techniques,the structures of obtained compounds were identified by physicochemical properties and spectral data.Their anti-inflammatory activities in vitro were evaluated by RAW264.7 cell inflammation model.RESULTS Eleven compounds were isolated and identified as wogonin(1),wogonin7-O-β-D-ethylglucuronic acid(2),wogonin7-O-β-D-methylglucuronic acid(3),(-)-syringaresinol(4),(-)-Pinoresinol 4-O-β-D-glucopyranoside(5),glucosyringic acid(6),methyl 3-(2-hydroxyphenyl)propionate(7),ethyl melilotate(8),syringaldehyde(9),catechol(10),and(E)-3-(3,4-dimethoxyphenyl)-N-phenethylacrylamide(11).Compared with the model group,NO production was reduced after administration of compounds 1-3 and 11(P＜0.05,P＜0.01).CONCLUSION Compounds 2-5,7-8,and 11 are isolated from Lycium genus for the first time.Compounds 1-3,and 11 have significant anti-inflammatory activities,and compound 2 has the best anti-inflammatory activity.
