Pathogenesis of asthenozoospermia in males:Progress in research

VernacularTitle:男性弱精子症发病机制的研究进展
Author: Lin QIAN ¹ ; Wen-Xin LI ; Han-Shu WANG ; Tao JING
Author Information

1. 青岛大学附属医院男性科,山东青岛 266000
Keywords: asthenozoospermia; sperm morphology; signaling pathway; energy metabolism
From: National Journal of Andrology 2024;30(10):936-941
CountryChina
Language:Chinese
Abstract: Asthenozoospermia is one of the major causes of male infertility,with complex pathogenesis,which involves abnor-malities in sperm morphology,signaling pathways,sperm motility-related energy metabolism,and other factors.Currently,extracellu-lar vesicles(EV)in the seminal plasma have been found with a positive effect on the spermatogenic process by releasing such self-en-capsulated molecules as DAN,RNA and proteins into target cells through direct fusion with the structure similar to the lipid bilayer on the surface,and thereby regulating their function.This article reviews the research progress in the pathogenesis of asthenozoospermia,aiming to provide some theoretical evidence for its further studies.