Live birth achieved by oocyte donation in a patient with 45,X/46,XY mixed gonadal dysgenesis:A case report and literature review
10.13263/j.cnki.nja.2024.05.004
- VernacularTitle:45,X/46,XY混合性性腺发育不全患者采用卵母细胞捐赠获得活产1例及文献复习
- Author:
Lu ZHENG
1
;
Jin-Zhao MA
;
Juan-Juan XU
;
Ying-Xia CUI
;
Bing YAO
;
Li CHEN
Author Information
1. 南京大学医学院附属金陵医院/东部战区总医院生殖医学科,江苏 南京 210002
- Keywords:
gonadal dysgenesis;
sex chromosome aberrations;
chimera;
45,X/46,XY mixed gonadal dysgenesis;
oocyte dona-tion;
intracytoplasmic sperm injection-embryo transfer;
pregnancy
- From:
National Journal of Andrology
2024;30(5):410-418
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the etiology,diagnosis and treatment of 45,X/46,XY mixed gonadal dysgenesis and the patients'clinical characteristics of conception,pregnancy and delivery,with purpose of improving the treatment and pregnancy manage-ment of the patients.Methods:We retrospectively analyzed the clinical data on a pregnant patient with45,X/46,XY mixed gonadal dysgenesis.Results:Based on the findings of hypoplasia of secondary sexual characteristics,streak gonads,chromosome karyotype incompatibility with social sex,and chromosome aberration in the gonadal tissue,the patient was diagnosed with 45,X/46,XY mixed gonadal dysgenesis,received oocyte donation and intracytoplasmic sperm injection-embryo transfer(ICSI-ET),and achieved a live birth.Conclusion:Female patients with 45,X/46,XY mixed gonadal dysgenesis are infertile,but can achieve pregnancy through o-ocyte donation.However,the incidence rates of pregnancy complications and abnormal delivery are higher in these patients than in nor-mal females.The perinatal outcomes can be improved by efficient treatment and pregnancy management of the patients.
