Focal therapy combined with immunotherapy for prostate cancer:Advances in studies
10.13263/j.cnki.nja.2024.04.012
- VernacularTitle:前列腺癌局灶治疗联合免疫治疗的研究进展
- Author:
Chuan-Guo ZHANG
1
;
Wei-Sheng LI
;
Cong ZHENG
;
Wen-Qiang HE
Author Information
1. 河南中医药大学第一附属医院泌尿外科,河南 郑州 450003;河南中医药大学第一临床医学院,河南 郑州 450003
- Keywords:
prostate cancer;
focal therapy;
immunotherapy;
oncology
- From:
National Journal of Andrology
2024;30(4):368-373
- CountryChina
- Language:Chinese
-
Abstract:
Prostate cancer(PCa)ranks as the second most prevalent malignancy among males worldwide at present,and its prevalence keeps rising.Focal therapy not only results in tumor necrosis but also encourages the release of autoantigens originating from the tumor into the bloodstream and activates the host immune system to effectively fight the tumor.However,focal therapy alone may not achieve the total ablation of cancer cells and may cause locoregional recurrence.Immunotherapy,by boosting the body's immune re-sponse,destroys tumor cells and prevents immune escape.Recent studies show that focal therapy combined with immunotherapy can produce a better clinical efficacy by enhancing the initial immune response,especially for low-to intermediate-risk confined PCa.This article offers some fresh perspectives on the management of PCa by reviewing the etiology and progression of the malignancy,focal ther-apeutic options,and advantages and vista of focal therapy combined with immunotherapy.
