Peripheral blood lymphocyte subsets are associated with the prognosis of prostate cancer

VernacularTitle:免疫细胞亚群与前列腺癌患者预后的关联性研究
Author: Fei MAO ¹ ; Chao YANG ; Lu JI
Author Information

1. 南京医科大学附属淮安第一医院泌尿外科,江苏淮安 223300
Keywords: lymphocyte subsets; prostate cancer; survival; CD4+T cells; NK cells
From: National Journal of Andrology 2024;30(4):321-325
CountryChina
Language:Chinese
Abstract: Objective:To explore the relationship between peripheral lymphocyte subsets and the survival of PCa patients.Methods:Using the Kaplan-Meier curve and log-rank test,we compared the overall survival(OS)and progression-free survival(PFS)of 100 PCa patients with different levels of lymphocytes.Meanwhile,we investigated the prognostic factors by univariate and multivariate Cox regression analyses,and counted the peripheral lymphocyte subsets by flow cytometry.Results:Both OS and PFS were significantly prolonged in the PCa patients with high levels of lymphocytes(≥747/μl),CD3+T cells(≥528/μl),CD4+T cells(≥315/μl),CD8+T cells(≥226/μl),B cells(≥105/μl)and NK cells(≥168/μl)(P<0.001).Univariate and multivariate Cox regression analyses indicated that CD4+T cells≤315/μl was an independent factor for the poor prognosis of PCa(HR=12.58,95%CI:3.00-52.73).Conclusion:Decreased absolute count of peripheral lymphocyte subsets is associated with the poor progno-sis of PCa.