Thyroid dysfunction and sarcopenia: An update
10.3760/cma.j.cn311282-20240411-00145
- VernacularTitle:甲状腺功能异常与肌肉减少症的研究进展
- Author:
Yuan WANG
1
;
Qian XING
Author Information
1. 大连医科大学附属第一医院内分泌与代谢病科 116021
- Keywords:
Sarcopenia;
Thyroid dysfunction;
Hyperthyroidism;
Hypothyroidism
- From:
Chinese Journal of Endocrinology and Metabolism
2024;40(10):887-890
- CountryChina
- Language:Chinese
-
Abstract:
Hyperthyroidism can lead to disturbances in protein homeostasis, mitochondrial dysfunction, and inflammation, which increase susceptibility to sarcopenia. Skeletal muscle function is regulated by triiodothyronine (T 3), and hypothyroidism can consequently impair muscle performance. However, subclinical hypothyroidism generally has minimal impact on the musculature of the elderly, potentially due to the interplay of various factors and adaptive response within the endocrine system. The decline in the ratio of free triiodothyronine to free thyroxine is associated with reduced deiodinase activity, which in turn negatively affects muscle function.
