Advance in islet β-cell senescence and type 2 diabetes mellitus
10.3760/cma.j.cn311282-20231018-00121
- VernacularTitle:胰岛β细胞衰老与2型糖尿病的研究进展
- Author:
Yao ZHENG
1
;
Gang CHEN
;
Wei LIN
Author Information
1. 福建医科大学省立临床医学院，福建省立医院内分泌科，福州 350001
- Keywords:
β-cells;
senescence;
Diabetes mellitus, type 2;
Cell regeneration;
Dedifferentiation;
Transdifferentiation
- From:
Chinese Journal of Endocrinology and Metabolism
2024;40(8):705-709
- CountryChina
- Language:Chinese
-
Abstract:
Type 2 diabetes mellitus is a complex disease characterized by insulin resistance, decreased β cell mass and dysfunction. Cell senescence refers to the permanent proliferation arrest of cells in response to various stress stimuli. This review summarizes the research progress on pancreatic islet β cell senescence and type 2 diabetes, aiming to provide a deeper understanding of the mechanisms underlying β cell senescence, β cell dysfunction in type 2 diabetes, and related therapeutic strategies.
