Title association between metabolically healthy overweight/obesity and risk of new-onset diabetes
10.3760/cma.j.cn311282-20230803-00019
- VernacularTitle:代谢健康型超重/肥胖与新发糖尿病的相关性研究
- Author:
Jing LIU
1
;
Jinping LI
Author Information
1. 宁夏医科大学总医院日间病房，银川 750003
- Keywords:
Adults;
Metabolically healthy overweight/obesity;
Diabetes mellitus
- From:
Chinese Journal of Endocrinology and Metabolism
2024;40(6):470-474
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the association between metabolically healthy overweight/obesity(MHO) and risk of new-onset diabetes among Chinese adults.Methods:This study was a secondary analysis of a retrospective cohort study recruiting 117 056 Chinese adults who received a health check at the Rich Healthcare Group from 2010 to 2016.Participants were classified into metabolically healthy non-obesity(MHNO), MHO, metabolically unhealthy non-obesity(MUNO), and metabolically unhealthy overweight/obesity(MUO) group according to body mass index and metabolic status at baseline. Kaplan-Meier method(log-rank test) was used to estimate the cumulative incidence of diabetes in each group. The Cox proportional hazards model was employed to estimate the hazard ratios( HR and 95% CI) for diabetes incidence across different obesity metabolic phenotype groups, followed by subgroup analysis. Results:A total of 117 056 Chinese adults were enrolled and the prevalence of MHO was 24.3%. During the follow-up time of (3.1±1.0) years, 2 685 new-onset diabetes adults occurred, resulting in a cumulative incidence rate of 2.3%. The cumulative incidences of MHNO, MHO, MUNO and MUO groups were 0.5%, 1.6%, 4.8%, and 7.9%, respectively, and there was a statistical difference ( χ2=1 224.164, P<0.001). Cox proportional hazards model showed that after adjusting for sex, age, fasting plasma glucose, smoking, alcohol drinking, and diabetes family history, the risk of new-onset diabetes in MHO group was 2.19 folds of MHNO group(95% CI 1.89-2.55). Additionally, the HR for diabetes in MUNO and MUO groups were 2.25(95% CI 1.93-2.64)and 3.00(95% CI 2.61-3.45). Conclusion:The MHO phenotype was significantly associated with an increased risk of new-onset diabetes in Chinese adults.
