Research progress on adenosine and its receptors in bone metabolism
10.3760/cma.j.cn311282-20231213-00210
- VernacularTitle:腺苷及其受体在骨代谢中的研究进展
- Author:
Xu LOU
1
;
Zhenlin ZHANG
;
Hua YUE
Author Information
1. 上海交通大学医学院附属第六人民医院骨质疏松和骨病专科、上海市骨疾病临床研究中心，上海 200233
- Keywords:
Adenosine;
Adenosine receptor;
Bone metabolism
- From:
Chinese Journal of Endocrinology and Metabolism
2024;40(5):450-454
- CountryChina
- Language:Chinese
-
Abstract:
Bone metabolism refers to the dynamic process in which osteoblast-mediated bone formation and osteoclast-mediated bone resorption are coupled, playing a crucial role in maintaining bone homeostasis. Adenosine, as an important component of purinergic signaling pathway, has multiple effects such as inhibition of inflammation, promotion of neovascularization, and modulation of osteoblast proliferation and osteoclast differentiation. The application of adenosine receptor agonists or targeted delivery of adenosine may present a novel approach for addressing clinical challenges such as osteoporosis and poor fracture healing. The purinergic signaling pathway activated by extracellular adenosine has been identified as a key signaling pathway for regulating bone tissue function and homeostasis. This article reviews the regulation of physiological bone metabolism by adenosine and its receptors, as well as the relationship between adenosine and metabolic bone diseases in pathological conditions, aiming to provide reference and direction for understanding the significance of adenosine pathway in the field of bone metabolism, and offer new insights for the treatment of metabolic bone diseases.
