Progress in tracers for SPECT and PET imaging of idiopathic pulmonary fibrosis

VernacularTitle:SPECT及PET探针在特发性肺纤维化中的显像研究进展
Author: Junyi LIU ¹ ; Yifan SHI ; Xiaoyun DENG ; Xiaohua ZHU
Author Information

1. 华中科技大学同济医学院附属同济医院核医学科，武汉　430030
Keywords: Idiopathic pulmonary fibrosis; Molecular probes; Tomography, emission-computed, single-photon; Positron-emission tomography; Trends
From: Chinese Journal of Nuclear Medicine and Molecular Imaging 2024;44(12):758-763
CountryChina
Language:Chinese
Abstract: Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic interstitial lung disease with an unclear etiology, characterized clinically by worsening dyspnea and dry cough. Its typical pathological features include excessive activation of fibroblasts and deposition of abundant extracellular matrix. Early diagnosis of IPF is challenging, treatment options are limited with significant constraints, and patients have a poor prognosis. SPECT and PET, as advanced representatives of molecular imaging, can reflect cellular functional abnormalities before anatomical structural abnormalities appear, thereby facilitating early diagnosis of IPF and optimization of treatment strategies, leading to improved prognosis. This review summarizes the research progress on molecular imaging targets and corresponding SPECT and PET probes in IPF.