extrahepatic malignant tumor after resection of hepatocellular carcinoma:clinical analysis of 9 cases
10.3877/cma.j.issn.2095-3232.2014.02.007
- VernacularTitle:肝细胞癌术后新发肝外恶性肿瘤患者九例临床分析
- Author:
Xiao JIANG
1
;
Liqun WU
;
Tianxiang LI
;
Jie KONG
;
Yang XIN
Author Information
1. 266003,青岛大学医学院附属医院肝胆外科
- Keywords:
Carcinoma,hepatocellular;
Hepatotectomy;
Neoplasms,second primary;
Prognosis
- From:
Chinese Journal of Hepatic Surgery（Electronic Edition）
2014;(2):92-95
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the incidence and prognosis of patients with de novo extrahepatic malignant tumor (EHM) after resection of hepatocellular carcinoma (HCC). Methods Clinical data of 9 patients who were diagnosed with de novo EHM during the follow-up of 686 patients with HCC undergoing radical hepatic resection from March 1997 to December 2010 in Department of Hepatobiliary Surgery, the Afifliated Hospital of Medical College, Qingdao University were analyzed retrospectively. The informed consents of all patients were obtained and the ethics committee approval was received. All the 9 patients were male. The incidence of EHM, age when diagnosed, site of disease, tumor type, and survive were analyzed. The preoperative T lymphocyte subgroup detection of patients was traced. Results The incidence of EHM was 1.3%(9/686), including 3 cases of lung cancer, 2 cases of gastric carcinoma, 2 cases of colon cancer, 1 case of thyroid carcinoma and 1 case of prostate cancer. The patients' age when diagnosed with EHM was 54 to 72 years old with a median age of 63 years old. The median interval time from HCC resection to diagnosis of EHM was 55 months (range:17 to 114 months). The 1-, 3-year cumulative survival rates after diagnosis of EHM were 74.1%, 0%. The cluster of differentiation (CD)4+/CD8+ratio before radical resection was<1.4 in 5 cases, including 3 cases with ratio<1.0. Conclusions The incidence of EHM is low in patients with HCC after operation, and the prognosis is poor. The weakened immunity before operation may be an important inducing factor.
