Advances on T cells related biomarkers of tumor immune microenvironment in non-small cell lung cancer

VernacularTitle:非小细胞肺癌免疫微环境T细胞相关生物标志物研究进展
Author: Yin YANG ¹ ; Nan BI
Author Information

1. 国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院放疗科，北京　100021
Keywords: Carcinoma, non-small-cell lung; Tumor immune microenvironment; T cell
From: Chinese Journal of Radiation Oncology 2024;33(10):971-977
CountryChina
Language:Chinese
Abstract: Immune checkpoint inhibitors (ICI) have recently revolutionized the treatment of non-small cell lung cancer (NSCLC). Tumor immune microenvironment (TIME), composed of immune inflammatory cells and related cytokines, is a key region regulated by ICI. The characteristics and dynamic changes of T cells within TIME are closely correlated with the therapeutic effect of ICI. In recent years, efforts have been devoted to exploring the potential biomarkers of T cells in NSCLC. In this review, advances in the phenotypes of TIME, T cell related biomarkers from tumor tissues and peripheral blood, and influencing factors were summarized.