Advances in lncRNA and circRNA in triple-negative breast cancer radiotherapy
10.3760/cma.j.cn113030-20230921-00098
- VernacularTitle:lncRNA和circRNA在三阴性乳腺癌放疗敏感性中的研究进展
- Author:
Guangmin WAN
1
;
Gang XU
Author Information
1. 郑州大学附属肿瘤医院（河南省肿瘤医院）放疗科，郑州 450008
- Keywords:
Triple negative breast neoplasms;
lncRNA;
circRNA;
Radiosensitivity;
Radioresistance
- From:
Chinese Journal of Radiation Oncology
2024;33(7):678-683
- CountryChina
- Language:Chinese
-
Abstract:
Breast cancer (BC) is one of the most common and severe malignant tumors worldwide. Currently, the prevalence of BC has surpassed that of lung cancer. Triple-negative breast cancer (TNBC) is a special subtype of breast cancer, charactered by poor prognosis, strong invasion, high recurrence rate, and low survival rate, etc. Currently, radiotherapy plays an adjuvant role in the treatment of TNBC and is being investigated in the neoadjuvant setting. Due to the radioresistance, clinical application of radiotherapy in TNBC patients remains challenging. How to improve the radiosensitivity is a hot topic in recent years. With the rapid development of whole-genome and transcriptome sequencing, increasing evidence suggests that long chain non-coding RNA (lncRNA) and circular RNA (circRNA) can play a significant function in regulating the radiosensitivity in TNBC. In this article, research progress in the role of lncRNA and circRNA in the radiosensitivity of TNBC was reviewed, aiming to provide a theoretical basis for elevating the clinical efficacy of radiotherapy in TNBC.
