The role of cellular senescence in radiation-induced brain injury and glioblastoma recurrence
10.3760/cma.j.cn113030-20231026-00146
- VernacularTitle:细胞衰老对放射性脑损伤和胶质母细胞瘤复发的作用
- Author:
Min FU
1
;
Guangyuan HU
Author Information
1. 华中科技大学同济医学院附属同济医院肿瘤科，武汉 430030
- Keywords:
Cellular senescence, radioactive;
Brain injuries, radiation induced;
Glioblastoma;
Recurrence
- From:
Chinese Journal of Radiation Oncology
2024;33(6):578-582
- CountryChina
- Language:Chinese
-
Abstract:
Radioactive cell senescence refers to the phenomenon in which cells undergo functional and morphological changes after being exposed to ionizing radiation, resulting in a permanent cessation of cell cycle, usually accompanied by inhibition of cell proliferation. Radiation induced cellular aging is the result of multiple molecular mechanisms, including DNA damage, cell cycle regulation, oxidative stress, and inflammatory response. Excessive or abnormal accumulation of senescent cells in the brain not only promotes the development of neurodegenerative diseases such as radiation induced brain injury, but also releases a large number of cytokines from senescent cells that contribute to the recurrence of glioblastoma. This article provides a review of the relationship between radioactive cellular senescence and the incidence of radiation brain injury and recurrence of glioblastoma.
