Analysis of dosimetric factors related to acute nausea and vomiting in intensity modulated radiotherapy for nasopharyngeal cancer
10.3760/cma.j.cn113030-20230906-00087
- VernacularTitle:鼻咽癌调强放疗中急性恶心和呕吐的相关剂量学因素分析
- Author:
Rong HUANG
1
;
Xiaoxu LU
;
Xueming SUN
;
Dingjie LI
;
Hui WU
Author Information
1. 郑州大学附属肿瘤医院（河南省肿瘤医院）放疗科，郑州 450008
- Keywords:
Radiotherapy;
Nausea and vomiting;
Organs at Risk;
Dosimetric factor analysis
- From:
Chinese Journal of Radiation Oncology
2024;33(6):506-510
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the dosimetric factors associated with acute nausea and vomiting (RINV) during intensity modulated radiotherapy for nasopharyngeal carcinoma.Methods:General clinical data and organs at risk (OAR) doses from 130 newly diagnosed early nasopharyngeal carcinoma patients who received radiation therapy alone in Henan Cancer Hospital from February 2018 to February 2023 were retrospectively analyzed. Dosimetric parameters were recorded, and the correlation between the parameters and the degree of nausea and vomiting was statistically analyzed using univariate and multivariate logistic regression models.Results:All 130 patients had symptoms of ≥ grade 1 nausea and vomiting. In the comparison of dosimetric parameters between patients with < grade 2 and ≥ grade 2 nausea, except the brainstem V 20 Gy, all parameters showed statistically significant differences (all P<0.05). The inner ear D max, and D max, D mean, V 10 Gy, V 20 Gy, V 30 Gy of the throat, oral cavity, pharyngeal constrictor, dorsal vagal complex (DVC) showed statistically significant differences between patients with grade 1 and grade 2 nausea (all P<0.05). The results of multivariate regression analysis showed that DVC V 30 Gy was a significant influencing factor in predicting the severity of nausea ( OR=73.95, 95% CI: 4.66-1172.60, P<0.001), and there was a significant correlation between oral V 30 Gy and the severity of vomiting ( OR=37.69, 95% CI: 1.26-1125.42, P=0.04). Conclusions:Even if OAR are exposed to lower doses of radiation, nausea or vomiting symptoms can still occur. The occurrence of RINV is significantly associated with DVC and oral radiation doses.
