Research progress in late toxicity of oropharyngeal cancer after radical intensity-modulated radiotherapy

VernacularTitle:口咽癌根治性调强放疗晚期不良反应研究进展
Author: Ya LIU ¹ ; Yaning ZHOU ; Dan ZUO ; Junlin YI ; Ye ZHANG
Author Information

1. 国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院放疗科，北京　100021
Keywords: Oropharyngeal neoplasms; Radiotherapy, intensity-modulated; Late effects; Adverse effects
From: Chinese Journal of Radiation Oncology 2024;33(5):461-465
CountryChina
Language:Chinese
Abstract: Intensity-modulated radiotherapy (IMRT) is a radical treatment for oropharyngeal carcinoma. The 5-year overall survival (OS) is approximately 60%, and 80% for human papillomavirus (HPV)-related oropharyngeal carcinoma patients. Late toxicities after IMRT, including xerostomia, dysphagia, hypothyroidism, trismus, osteoradionecrosis and caries, and lower cranial neuropathy, seriously affect the quality of life of long-term survivors. The research on treatment de-intensification for HPV-related oropharyngeal cancer has been widely carried out at home and abroad, but there is little research focusing on late toxicity. In this article, related research progress in the incidence, treatment, prediction of late toxicity after IMRT was reviewed, aiming to provide reference for research on radiation-induced injury in de-intensification therapy research, thereby further optimizing comprehensive treatment strategies.