Serum insulin-like growth factor 2 mRNA binding protein 3 levels and its clinical significance in rheumatoid arthritis
10.3760/cma.j.cn141217-20240110-00017
- VernacularTitle:类风湿关节炎患者血清胰岛素样生长因子ⅡmRNA结合蛋白3水平及其临床意义
- Author:
Zhengfang ZHANG
1
;
Jian WANG
;
Chaoqun WANG
;
Lulu JIN
Author Information
1. 温州医科大学附属东阳医院风湿免疫科，东阳 322100
- Keywords:
Arthritis, rheumatoid;
C-reactive protein;
Enzyme-linked immunosorbent assay;
Insulin-like growth factor 2 mRNA binding protein 3
- From:
Chinese Journal of Rheumatology
2024;28(11):829-832
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the levels and clinical significance of insulin-like growth factor 2 mRNA binding protein 3 (IGF2BP3) in the serum of patients with rheumatoid arthritis (RA).Methods:Serum samples from 82 patients with RA admitted to the Affiliated Dongyang Hospital to wenzhou Medical Umiversity from December 2019 to February 2022 were collected as the experimental group and the serum of 45 healthy individuals from the physical examination center as the control group. Serum levels of IGF2BP3 were measured using enzyme-linked immunosorbent assay (ELISA), and the t-test was used to compare the difference in IGF2BP3 levels between the two groups. The value of IGF2BP3 in the diagnosis of RA was analyzed by plotting a ROC curve, and after determining the cut-off value, serum IGF2BP3 levels were divided into high and low levels. The relationship between serum IGF2BP3 levels and various clinical features of RA patients was then analyzed using the chi-square test. Results:The serum levels of IGF2BP3 in RA patients were significantly higher compared to healthy controls [(0.60±0.55)ng/ml vs. (0.31±0.17)ng/ml, t=4.42, P<0.001]. The cut-off value of IGF2BP3 was determined as 0.308 ng/ml. The high level of IGF2BP3 was significantly more prevalent in active RA patients (78.8%, 41/52) than in non-active patients (56.7%, 17/30) ( χ2=4.52, P=0.033). The level of IGF2BP3 was positively correlated with the C-reactive protein level ( r=0.29, P=0.008), and the prevalence of high IGF2BP3 level in the elevated CRP group (82.0%, 41/50) was significantly higher than that in the decreased CRP group (54.8%, 17/31) ( χ2=6.94, P=0.008). The AUC of the ROC curve for serum IGF2BP3 in the diagnosis of RA was 0.700, with a sensitivity of 70.7% and a specificity of 60.0%. When using 0.575, 0.689, and 0.727 ng/ml as the cut-off values for serum IGF2BP3, the sensitivity was 34.1%, 26.8%, and 23.2%, respectively, with the specificity of 95.6%, 97.8%, and 100.0%, respectively. Conclusion:The level of serum IGF2BP3 is closely associated with RA disease progression.
