Application of cell transplantation technology in the repair of spinal cord injury: a review

VernacularTitle:细胞移植技术在脊髓损伤修复中应用的研究进展
Author: Pengcheng HUA ¹ ; Weihu MA
Author Information

1. 宁波大学医学部，宁波　315201
Keywords: Spinal cord injuries; Cell transplantation; Stem cells
From: Chinese Journal of Trauma 2024;40(10):947-954
CountryChina
Language:Chinese
Abstract: Spinal cord injury is a serious disease of the central nervous system characterized by high disability and mortality, and shows an increasing incidence over year. Traditional treatment methods include surgery, medication and rehabilitation therapy, but the therapeutic outcomes are generally unsatisfactory and the functional recovery of patients is very limited. In recent years, cell transplantation technology, with a role in promoting neuron regeneration and neural pathway reconstruction by transplanting exogenous cells to the injured site, has become a promising treatment strategy for spinal cord injury. However, at present, cell transplantation technology is still faced with problems such as the diversified transplanted cell types, poor survival rate of transplanted cells, and uncertainty in the timing and dosage of transplantation in the repair of spinal cord injury. To this end, the authors reviewed the research progress in the application of cell transplantation technology in the repair of spinal cord injury, aiming to provide a reference for the clinical treatment.