Pro-angiogenetic effects of stem cell therapy for spinal cord injury: a review
10.3760/cma.j.cn501098-20240301-00171
- VernacularTitle:干细胞治疗促血管形成修复脊髓损伤的作用研究进展
- Author:
Yulin ZHAO
1
;
Heng WANG
;
Yang LU
;
Cheng CHEN
;
Xiaoqing CHEN
Author Information
1. 南通大学附属医院脊柱外科，南通大学医学院，南通 226001
- Keywords:
Stem cells;
Spinal cord injuries;
Neovascularization, physiologic;
Paracrine intercellular communication;
Extracellular vesicles
- From:
Chinese Journal of Trauma
2024;40(8):743-752
- CountryChina
- Language:Chinese
-
Abstract:
Spinal cord injury is one of the most serious neurological disorders. Revascularization after spinal cord injury can provide nutritional support to maintain the homeostasis of the neuronal networks and facilitate the recovery of neurological function. Promoting angiogenesis is a key repair strategy for spinal cord injury. However, since the ability of blood vessels to repair themselves is limited, external interventions are often needed to promote angiogenesis after spinal cord injury, among which medications and physical therapy are common ways, but their therapeutic effects are very limited. Stem cell therapy is an important way to promote the repair of the injured vessels in the spinal cord, with multiple sources of cells such as neural stem cell (NSC) and mesenchymal stem cell (MSC). The stem cell paracrine cytokines and extracellular vesicles (EVs) are often used to promote angiogenesis in the injured spinal cord. In addition, stem cells are capable of multiple differentiation and can effectively differentiate into endothelial cells, thus promoting angiogenesis. Currently, there is a lack of comprehensive understanding of the pro-angiogenetic effects of the stem cells after spinal cord injury. For this purpose, the authors reviewed the researches in the pro-angiogenetic pathways of the stem cells and the pro-angiogenetic effects of stem cell therapy after spinal cord injury, aimed at providing references for relevant basic research on the pro-angiogenetic effects of stem cells after spinal cord injury and its clinical treatment.
