Clinical Manifestations of Mononeuritis Multiplex in Patients with Rheumatoid Arthritis.
- Author:
Jin Hyun WOO
1
;
Kyung Hae LEE
;
Yong Wook PARK
;
Hye Soon LEE
;
Wan Sik UHM
;
Tae Hwan KIM
;
Jae Bum JUN
;
Sang Cheol BAE
;
Dae Hyun YOO
Author Information
1. Department of Internal Medicine, The Hospital for Rheumatic Diseases, Hanyang University College of Medicine, Seoul, Korea. dhyoo@hanyang.ac.kr
- Publication Type:Original Article
- Keywords:
Mononeuritis multiplex;
Rheumatoid arthritis;
Vasculitis
- MeSH:
Arthritis, Rheumatoid*;
C-Reactive Protein;
Female;
Foot;
Humans;
Immunosuppressive Agents;
Korea;
Lower Extremity;
Male;
Medical Records;
Mononeuropathies*;
Muscle Weakness;
Paresthesia;
Prevalence;
Retrospective Studies;
Rheumatoid Factor;
Skin Ulcer;
Upper Extremity;
Vasculitis
- From:The Journal of the Korean Rheumatism Association
2004;11(2):90-95
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: Mononeuritis multiplex is an extra-articular manifestation associated with rheumatoid arthritis. This study set out to investigate its clinical characteristics in Korea. MEHTODS: Clinical characteristics and laboratory data were compared retrospectively by review of medical records between 12 patients with mononeuritis multiplex (case) and randomly selected 116 age-matched patients without mononeuritis multiplex in patients with rheumatoid arthritis (control). RESULTS: Mean age of the case group was 51.8+/-8.4 years old with 7 males and 5 females which showed higher prevalence of male gender compared to the control group (p<0.05). There was no difference in mean duration of disease between two groups. Upper limbs, lower limbs and both upper and lower limbs were involved in 3, 7 and 2 patients, respectively. Major symptoms were tingling (66.6%), paresthesia (33.3%), pain (33.3%), foot drop (33.3%), or muscle weakness (16.7%). Skin ulceration was accompanied in 3 patients, but vasculitis of other organs was not found. Mean C-reactive protein level in the case group was 7.6+/-6.7 mg/dL, which was higher compared to 2.4+/-3.1 mg/dL in the control group (p<0.05). Rheumatoid factor was positive in 83.3% of the case, however positive rate and titer showed no significant difference with the control group. There was no difference in other extra-articular manifestations between two groups. Six patients were treated with glucocorticoid and immuno-suppressants and 6 patients with only glucocorticoid1 for 6.8+/-7.1 weeks. Symptoms improved after treatment in 10 patients but, it lasted in 2 patients. CONCLUSION: Rheumatoid arthritis associated mononeuritis multiplex was more prevalent in males with higher CRP levels, and responded well to medical intervention including glucocorticoid, and immunosuppressants.
