Regulatory Mechanism of Mitochondrial Autophagy in Myocardial Ischemia/Reperfusion Injury Based on the Theory of"Deficiency Qi Retention"
10.19879/j.cnki.1005-5304.202309444
- VernacularTitle:基于"虚气留滞"理论探讨线粒体自噬在心肌缺血再灌注损伤中的调控机制
- Author:
Meng YANG
1
;
Siyuan HU
;
Lin LI
;
Zhixi HU
Author Information
1. 湖南中医药大学中医学院,湖南 长沙 410208
- Keywords:
myocardial ischemia/reperfusion injury;
deficiency qi retention;
mitochondrial autophagy;
regulatory mechanism;
Chinese materia medica
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2024;31(10):8-13
- CountryChina
- Language:Chinese
-
Abstract:
Mitochondrial autophagy is the main regulator of cardiac homeostasis and function,and its dysfunction can lead to calcium overload,excessive opening of mitochondrial permeability transition pore,abnormal material metabolism,and other damaging changes,reducing myocardial cell activity,which is a key pathological mechanism of myocardial ischemia/reperfusion injury(MIRI)."Deficiency qi retention"is the core mechanism of MIRI,and mitochondrial autophagy is an important mechanism of MIRI,which runs through the every stage of its occurrence and development.This article took"deficiency qi retention"as the entry point to explore the association between mitochondrial autophagy and MIRI,explained the scientific connotation of"deficiency qi retention",and summarized the progress of research on the method of supplementing deficiency and promoting stagnation for prevention and treatment of MIRI,with a view to providing theoretical reference for clinical diagnosis and treatment of MIRI.
