Relationship between the expression of low-level placental growth factor in the second trimester of pregnancy and pathological obstetrics
10.3760/cma.j.cn101721-20240701-00201
- VernacularTitle:孕中期低水平胎盘生长因子的表达与病理产科的关系
- Author:
Xiaoyan HAN
1
;
Hua YANG
Author Information
1. 首都医科大学附属北京友谊医院妇产科，北京 100050
- Keywords:
Second trimester of pregnancy;
Placental growth factor;
Pathology
- From:
Clinical Medicine of China
2024;40(6):443-446
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the relationship between the low expression of placenta growth factor (PLGF) in the second trimester of pregnancy and obstetrics pathology.Methods:A total of 177 cases of pregnant women in the second-trimester who received regular prenatal checkups in the Department of Obstetrics, Beijing Friendship Hospital, Capital Medical University from March 2023 to May 2024 were selected as research subjects. Among them, 87 cases expressed low level of PLGF; 90 cases with normal PLGF were randomly selected as the control group. The measurement data of normal distribution were expressed as xˉ± s, the comparison of mean between two groups was performed by independent sample t-test, the percentage was calculated by counting data, and the comparison of rates between two groups was performed by χ2 test. P≤0.05 was statistically significant. Results The incidence of preeclampsia was 13.79% (12/87) in the low PLGF group and 2.22% (2/90) in the control group. There was significant difference between the two groups ( χ2=8.13, P=0.004). In 87 cases with low level of PLGF, there were 10 cases of fetal growth restriction and 11 cases of premature delivery during pregnancy. Compared with normal pregnancy group, the rate of fetal growth restriction and premature delivery in low level of PLGF group was significantly higher, there was significant difference between the two groups ( χ2=4.33, P=0.037; χ2=5.26, P=0.022). The incidence of fetal distress in the PLGF low-level group was 10.34% (9/87), while the incidence of fetal distress in the PLGF normal group was 4.44% (4/90). There was no statistically significant difference in the incidence of fetal distress between the two groups ( χ2=2.26, P=0.132). In this study, 3 cases (3.45%, 3/87) of placental abruption occurred in the PLGF low-level group, while only 1 case (1.11%, 1/90) occurred in the PLGF normal group. Although the incidence of placental abruption in the PLGF group was higher than that in the PLGF normal group, the difference between the groups was not statistically significant ( χ2=0.29, P=0.589). Conclusion:The decrease of PLGF in the second trimester of pregnancy is closely related to preeclampsia, fetal growth restriction and premature delivery. For pregnant women with low level of PLGF.
