Dynamic Susceptibility Contrast-Enhanced Perfusion Weighted Imaging Histogram in Predicting Chemotherapy Response of Primary Central Nervous System Lymphoma
10.3969/j.issn.1005-5185.2024.05.005
- VernacularTitle:动态磁敏感对比增强灌注加权成像直方图预测原发性中枢神经系统淋巴瘤化疗反应的价值
- Author:
Nan ZHANG
1
;
Guoli LIU
;
Mingxiao WANG
;
Lin MA
Author Information
1. 解放军医学院,北京 100853;解放军总医院第一医学中心放射诊断科,北京 100853
- Keywords:
Neurolymphomatosis;
Central nervous system neoplasms;
Lymphoma,non-Hodgkin;
Magnetic resonance imaging;
Perfusion weighted imaging;
Methotrexate;
Chemotherapy,adjuvant
- From:
Chinese Journal of Medical Imaging
2024;32(5):439-446,460
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To investigate the value of pre-treatment relative cerebral blood flow(rCBF)and relative cerebral blood volume histogram of dynamic susceptibility contrast-enhanced perfusion weighted imaging in predicting the chemotherapy response of primary central nervous system lymphoma(PCNSL)patients.Materials and Methods Thirty-eight PCNSL patients with fifty-seven lesions treated with high-dose methotrexate chemotherapy from September 2016 to October 2023 were retrospectively involved in the study.The patients were divided into response group of 30 patients and non-response group of 8 patients.Region of interest was drawn in cerebral blood flow and cerebral blood volume images,and histogram paraments were extracted.Univariate and multivariate Logistic regression analysis were performed to identify the independent predictors for chemotherapy response in PCNSL,and then combined prediction model was constructed.The area under the receiver operating characteristic curve was used to compare the predictive performance of different paraments and combined model.Results The number of lesions(OR=9.726,95％CI 1.070-88.397,P=0.043)and rCBF90(OR=0.224,95％CI 0.072-0.704,P=0.010)were the independent predictors for chemotherapy response with the area under the curve of 0.681 and 0.798,respectively.The combined model of rCBF90 and the numbers of lesions showed the best predictive performance with the area under the curve of 0.846.Conclusion The pre-treatment quantitative parameters rCBF and relative cerebral blood volume of dynamic susceptibility contrast-enhanced perfusion weighted imaging could be used for predicting the response to high-dose methotrexate chemotherapy in PCNSL patients,and the rCBF90 is an independent predictor of chemotherapy response.
