Integrated 18F-FET PET/MR combined with arterial spin labeling for predicting isocitrate dehydrogenase(IDH)genotype and Ki-67 index of glioma
10.13929/j.issn.1003-3289.2024.10.005
- VernacularTitle:一体化18F-FET PET/MR联合动脉自旋标记预测脑胶质瘤异柠檬酸脱氢酶(IDH)基因型及Ki-67指数
- Author:
Jie BAI
1
;
Xiaoran LI
;
Jie LU
Author Information
1. 首都医科大学宣武医院放射与核医学科,北京 100053;磁共振成像脑信息学北京市重点实验室,北京 100053
- Keywords:
glioma;
arterial spin labeling;
positron-emission tomography;
magnetic resonance imaging;
isocitrate dehydrogenase;
Ki-67 antigen
- From:
Chinese Journal of Medical Imaging Technology
2024;40(10):1476-1480
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the value of integrated 18F-FET PET/MR combined with arterial spin labeling(ASL)for predicting isocitrate dehydrogenase(IDH)genotype and Ki-67 index of glioma.Methods Eighty patients with glioma were retrospectively enrolled.The patients were divided into mutant group(n=31)and wild group(n=49)according to IDH genotype,or into high index group(＞10％,n=57)and low index group(≤10％,n=23)according to Ki-67 index.Integrated 18F-FET PET/MR was performed to obtain PET,structural MR and ASL images,simultaneously.The maximum and mean target-to-background ratio(TBRmax,TBRmean),the maximum and mean normalized cerebral blood flow(nCBFmax,nCBFmean)were calculated based on tumor's volume of interest(VOI)and were compared between groups.Receiver operating characteristic curve was drawn,the area under the curve(AUC)was calculated to evaluate the efficacy of PET/MR parameters,ASL parameters,optimal PET/MR+optimal ASL parameters(dual-mode parameters),as well as clinical+dual-mode parameters(combined parameters)for predicting IDH genotype and Ki-67 index of glioma.Results Patients'age,proportion of high WHO grade,TBRmax,TBRmean,nCBFmax and nCBFmean in mutant group were all lower than those in wild group(all P＜0.01).Patients'age,proportion of high WHO grade,TBRmax,TBRmean and nCBFmax in high index group were all higher than those in low index group(all P＜0.01).AUC of TBRmax,TBRmean,nCBFmax,nCBFmean,dual-mode parameters(TBRmax+nCBFmax)and combined parameters(age+TBRmax+nCBFmax)for predicting IDH genotype of glioma was 0.758,0.702,0.773,0.708,0.816 and 0.866,respectively.AUC of TBRmax,TBRmean,nCBFmax,dual-mode parameters(TBRmax+nCBFmax),combined parameters(age+TBRmax+nCBFmax)for predicting Ki-67 index of glioma was 0.823,0.719,0.701,0.823 and 0.854,respectively.Conclusion Integrated 18F-FET PET/MR combined with ASL could predict IDH genotype and Ki-67 index of gliomas effectively.
