Dynamic contrast enhanced MRI for evaluating early efficacy of chemotherapy in rabbit models of VX2 malignant bone tumor
10.13929/j.issn.1003-3289.2024.10.001
- VernacularTitle:动态对比增强MRI评估化学治疗用于兔VX2恶性骨肿瘤模型早期效果
- Author:
Jing ZHANG
1
;
Cheng DONG
;
Xiaoli LI
;
Wenjian XU
Author Information
1. 青岛大学附属医院放射科,山东青岛 266003
- Keywords:
bone neoplasms;
antineoplastic protocols;
animal experimentation;
magnetic resonance imaging
- From:
Chinese Journal of Medical Imaging Technology
2024;40(10):1457-1460
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the value of dynamic contrast enhanced MRI(DCE-MRI)for evaluating the early efficacy of chemotherapy in rabbit models of VX2 malignant bone tumor.Methods Models of VX2 malignant bone tumor were established in 30 rabbits,among which 14 were treated with intravenous cisplatin by 7 mg/kg body mass(chemotherapy group),while the other 16 were injected with equal dose of normal saline(control group).Non-contrast MRI and DCE-MRI were acquired 2 weeks after tumor implantation(before intervention)and 3 days later injection(after intervention),respectively.Point-to-point comparisons were performed between images and pathological findings,and the values of volume transfer constant(Ktrans),rate constant(Kep),extravascular and extracellular volume fraction(Ve),plasma volume fraction(Vp)and microvessel density(MVD)in tumor region were obtained.MRI findings before and after intervention within groups,as well as those after intervention were compared between groups.The efficacy of the above parameters forjudging whether the tumor being treated with chemotherapy or not was evaluated with receiver operating characteristic(ROC)curve and the area under the curve(AUC),and the correlations between DCE-MRI parameters after intervention and MVD were analyzed.Results No statistical difference of the maximum diameter of tumors shown on plain MRI was found before and after intervention in chemotherapy group(P＞0.05).Compared with those before intervention,Ktrans and Kep in tumor region decreased in chemotherapy group but increased in control group after intervention(allP＜0.05),while no significant difference of Ve nor Vp was found in both groups(all P＞0.05).Ktrans and Kep in chemotherapy group were lower than those in control group(both P＜0.05),while no significant difference of Ve nor Vp between groups after intervention(both P＞0.05).The AUC of Ktrans,Kep,Ve and Vp for judging whether the tumor treated with chemotherapy or not was 0.964,0.933,0.317 and 0.455,respectively.MVD in tumor regions in chemotherapy group was lower than that in control group after intervention(P＜0.05).Ktrans and Kep in tumor region in both groups were positively correlated with MVD(r=0.876,0.881,both P＜0.05),while Ve and Vp did not significantly correlated with M VD(r=0.118,0.202,both P＞0.05).Conclusion DCE-MRI quantitative parameters Ktrans and Kep could be used to sensitively observe the early reflection of rabbit models of VX2 malignant bone tumor to chemotherapy and changes of MVD.
