Two-phase hemodynamic analysis of intracranial arteries based on high-resolution magnetic resonance tube wall imaging
10.3969/j.issn.1005-202X.2024.11.015
- VernacularTitle:基于高分辨率磁共振管壁成像的颅内动脉两相血流动力学分析
- Author:
Yuxiang CUI
1
;
Weihua CAI
;
Fei XIANG
;
Yuan TIAN
;
Lulu LI
;
Hong GUO
Author Information
1. 哈尔滨医科大学附属第一医院心内科,黑龙江哈尔滨 150000
- Keywords:
ischemic stroke;
intracranial artery;
two-phase flow;
non-Newtonian fluid;
hemodynamics;
magnetic resonance angiography
- From:
Chinese Journal of Medical Physics
2024;41(11):1421-1427
- CountryChina
- Language:Chinese
-
Abstract:
Based on high-resolution magnetic resonance tube wall imaging,reverse medical engineering modeling techniques are used to obtain individualized intracranial artery models of high prevalence in ischemic stroke.Three types of intracranial artery models,including Newtonian fluid model,non-Newtonian fluid model and non-Newtonian fluid with two-phase flow model,are established for transient numerical simulations using computational fluid dynamics method.The hemodynamic parameters such as blood flow field,wall shear stress distribution and erythrocyte volume distribution are analyzed to investigate the possible mechanisms involved in the formation and progression of intracranial atherosclerosis.It is found that blood flow velocity increased significantly at the end of the internal carotid artery and the middle cerebral artery.Low-speed vortex flow and disturbed flow appear in the local vessels.The difference in blood flow velocity between the center and the edge of the wall is large,with an obvious low-flow velocity area on the outer side.A clear central core area is formed in the stenotic wall under the action of high-speed blood flow,resulting in thinner edge layer and lower erythrocyte volume fraction.The combination of low erythrocyte distribution in the edge layer and low flow velocity on the outer side of the wall exacerbates endothelial cell necrosis,hypoxia,endothelial dysfunction,and leads to atherosclerosis.Compared with Newtonian and non-Newtonian fluid models,non-Newtonian fluid with two-phase flow model has greater variability for hemodynamic parameters and shows higher fidelity in simulating blood flow,which provides a reference for clinical diagnosis and treatment of cerebrovascular diseases.
