Effects of Mitochondrial Dysfunction and Adenosine Monophosphate-activated Protein Kinase/Peroxisome Proliferator-activated Receptor-γ Coactivator 1α Signal Pathway on Pathophysiological Mechanism of Diabetic Peripheral Neuropathy
10.3881/j.issn.1000-503X.2018.01.019
- VernacularTitle:线粒体功能异常与腺苷酸活化蛋白激酶/过氧化物酶体增殖活化受体γ共激活因子1α信号途径在糖尿病周围神经病变机制中的作用
- Author:
Qian ZHANG
1
;
Xiaochun LIANG
Author Information
1. 中国医学科学院北京协和医学院北京协和医院中医科
- Keywords:
adenosine monophosphate-activated protein kinase;
peroxisome proliferator-activated receptor-γ coactivator 1α;
mitochondria;
diabetic peripheral neuropathy
- From:
Acta Academiae Medicinae Sinicae
2018;40(1):122-127
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic peripheral neuropathy (DPN) is a neurodegenerative disease induced by chronic hyperglycemia.Its pathophysiologic processes including neurons loss,nerve demyelination,axonal degeneration,and disorders in nerve repair and regeneration may be associated with mitochondrial dysfunction.Ultrastructural abnormalities of mitochondria,mitochondrial proteomic changes,dysfunctions of mitochondrial electron transport chain and mitochondria have been implicated as the etiological factors of DPN.These abnormal conditions may be relevant to adenosine monophosphate-activated protein kinase/peroxisome proliferator-activated receptor-γ coactivator 1α signaling axis disorder.Therefore,therapies targeting this pathway may help to protect nerves and delay the progression of DPN.
