The expression and clinical significance of c-Src in cholangiocarcinoma
10.3760/cma.j.cn431274-20231210-00660
- VernacularTitle:c-Src在胆管癌中的表达及其临床意义
- Author:
Zaxi BASANG
1
;
Xin DU
;
Kangfan LIU
;
Wei LIU
;
Laque GADAN
;
Hongwei CHEN
Author Information
1. 拉萨市人民医院普外科，拉萨 850011
- Keywords:
Bile duct neoplasms;
Cell sarcoma
- From:
Journal of Chinese Physician
2024;26(4):573-576
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expression of c-Src in cholangiocarcinoma (CCA) and its relationship with clinical pathological features.Methods:The bile duct tissue of 68 CCA patients who underwent surgical resection at the Lhasa People′s Hospital from January 2017 to December 2022 and the normal bile duct tissue of 18 patients with common bile duct stones were selected. The expression of c-Src in bile duct tissue was detected using SP immunohistochemistry, and the expression of c-Src in CCA and its relationship with clinical pathological features were analyzed.Results:The positive rate of c-Src in CCA tissue was 58.82%(40/68), significantly higher than the 16.67%(3/18, P<0.01) in normal bile duct tissue. The expression score of c-Src in CCA tissues with metastasis was significantly higher than that in CCA tissues without metastasis ( P<0.01). Conclusions:The expression of c-Src is significantly increased in CCA tissues, and the expression of c-Src is also significantly increased in CCA tissues with metastasis, indicating that c-Src promotes the invasion and metastasis of CCA.
