Influencing factors and predictive value of proteinuria in type 2 diabetes patients
10.3760/cma.j.cn431274-20230825-00156
- VernacularTitle:2型糖尿病患者蛋白尿的影响因素及其预测价值
- Author:
Yan ZHANG
1
;
Ning ZHANG
;
Li ZHANG
;
Rui ZHANG
Author Information
1. 阜阳市中医医院检验科，阜阳 236000
- Keywords:
Diabetes mellitus, type 2;
Proteinuria;
Risk factors
- From:
Journal of Chinese Physician
2024;26(4):529-532
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the influencing factors and predictive value of proteinuria in patients with type 2 diabetes (T2DM).Methods:A total of 200 T2DM patients from the Fuyang Traditional Chinese Medicine Hospital from January 2022 to May 2023 were selected and divided into proteinuria negative group and proteinuria positive group based on the urinary albumin to creatinine ratio (UACR). We compared the basic characteristic data and laboratory examination data of two groups of patients, and analyzed the independent risk factors for proteinuria in T2DM patients through univariate and multivariate analysis. We also analyzed the predictive value of independent risk factors for proteinuria in T2DM patients.Results:Univariate analysis showed that the duration of T2DM, systolic blood pressure, total cholesterol, low-density lipoprotein cholesterol, blood creatinine, uric acid, fasting blood glucose, glycated hemoglobin levels, body mass index (BMI)≥25 kg/m 2, and the proportion of vitamin D deficiency in the proteinuria positive group were all higher than those in the proteinuria negative group (all P<0.05). Multivariate logistic regression analysis showed that BMI ( OR=1.451), duration of T2DM ( OR=1.462), systolic blood pressure ( OR=1.078), uric acid ( OR=1.005), fasting blood glucose ( OR=1.195), and vitamin D deficiency ( OR=3.391) were all independent risk factors for proteinuria in T2DM patients (all P<0.05). The receiver operating characteristic (ROC) curve shows that BMI, duration of T2DM, systolic blood pressure, uric acid, fasting blood glucose, and vitamin D deficiency all have certain predictive power for proteinuria in T2DM patients. Conclusions:BMI, T2DM course, systolic blood pressure, uric acid, fasting blood glucose and vitamin D deficiency are independently related to proteinuria in T2DM patients, and all of them have certain predictive value for the occurrence of proteinuria. Early intervention of related factors is expected to delay the development of diabetes nephropathy.
