Effect of ezetimibe combined with rosuvastatin on serum PTX3 and sCD40L levels in patients with cerebral infarction complicated with carotid atherosclerosis plaque
10.12173/j.issn.2097-4922.202406044
- VernacularTitle:依折麦布联合瑞舒伐他汀对脑梗死合并颈动脉粥样硬化斑块患者血清PTX3、sCD40L水平的影响
- Author:
Jie ZHANG
1
;
Haiyan ZHANG
;
Yu WANG
;
Wei CAO
;
Lin CAO
Author Information
1. 邢台市中心医院健康体检中心(河北邢台 054000)
- Keywords:
Ezetimibe;
Rosuvastatin;
Cerebral infarction;
Carotid atherosclerotic plaque;
Pentraxin 3;
Soluble CD40 ligand
- From:
China Pharmacist
2024;28(9):57-64
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of ezetimibe combined with rosuvastatin on serum levels of pentraxin 3(PTX3)and soluble CD40 ligand(sCD40L)in patients with cerebral infarction(CI)complicated with carotid atherosclerosis(CAS)plaque.Methods The data of patients with CI and CAS plaque diagnosed and treated in the Department of Neurology,Xingtai Central Hospital from January 2021 to January 2023 were retrospectively analyzed.According to the diagnosis and treatment plans of the patients,they were divided into a combination group(ezetimibe combined with rosuvastatin)and a control group(rosuvastatin).The clinical efficacy,National Institutes of Health Stroke Scale(NIHSS),activity of daily living(ADL)scores,arterial plaque scores,blood lipid index[total cholesterol(TC),triglyceride(TG),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein(LDL-C)]and serum index(PTX3,sCD40L level)before and 6 months after treatment were compared between the two groups.Results A total of 200 patients were included in the study,with 100 in both the control and combination groups.After treatment,the total effective rate of the combination group was higher(P＜0.05).After treatment,NIHSS,ADL scores,arterial plaque scores,TC,TG,LDL-C,HDL-C levels,serum PTX3 and sCD40L levels in both groups were significantly improved compared with those before treatment(P＜0.05),and the improvement degree of the combination group was better than that of the control group(P＜0.05).Conclusion Ezetimibe combined with rosuvastatin may have certain value in CI patients complicated with CAS,which can improve nerve function,stabilize and reverse CAS plaques,regulate lipid levels and serum PTX3 and sCD40L levels,and improve the quality of life.
