Research progress of N6-methyladenosine in diseases
10.12173/j.issn.1008-049X.202403096
- VernacularTitle:N6-甲基腺苷在疾病中的研究进展
- Author:
Wang PAN
1
;
Aihua ZHOU
Author Information
1. 江苏大学药学院(江苏镇江 212013)
- Keywords:
N6-methyladenosine;
methylase;
demethylase;
Cellular processes;
Lung cancer;
Pulmonary fibrosis;
Renal cell carcinoma;
Acute kidney injury;
Asthma;
Alzheimer's disease;
Research progress
- From:
China Pharmacist
2024;27(8):1436-1444
- CountryChina
- Language:Chinese
-
Abstract:
N6-methyladenosine modification is regulated by methylase and demethylase,resulting in a dynamic and reversible process.Changes in m6A levels are involved in a wide range of cellular processes,including nuclear RNA output,mRNA metabolism,protein translation,and RNA splicing,and have strong associations with various diseases.The purpose of this paper is to generalize and summarize the role and mechanism of the change of m6A expression level in mRNA in three common diseases,as well as the research trend based on the change of m6A level in mRNA as a drug intervention target.
