Research progress of factors influencing the efficacy of nonsteroidal anti-inflammatory drugs
10.12173/j.issn.1008-049X.202402133
- VernacularTitle:非甾体抗炎药疗效影响因素的研究进展
- Author:
Gulinigeer·AINIWAER
1
;
Han XIE
;
Xinyi CHEN
;
Xudong MA
;
Weihong GE
;
Feng YU
Author Information
1. 中国药科大学南京鼓楼医院药学部(南京 210008);中国药科大学基础医学与临床药学学院(南京 210009)
- Keywords:
Non-steroidal anti-inflammatory drugs;
Differences in efficacy;
Drug metabolizing enzymes;
CYP2C9;
Cyclooxygenase;
Intestinal microbiota;
Osteoarthritis;
Rheumatoid arthritis;
Gene polymorphism
- From:
China Pharmacist
2024;27(5):885-891
- CountryChina
- Language:Chinese
-
Abstract:
Nonsteroidal anti-inflammatory drugs(NSAIDs)are widely used to treat osteoarthritis,rheumatoid arthritis,and acute and chronic painful diseases.Significant interindividual heterogeneity in the efficacy of NSAIDs has been found in patients,which can lead to treatment failure or life-threatening adverse drug reactions.This review will discuss the causes of the variability in the efficacy of NSAIDs in terms of CYP2C9 enzyme gene polymorphism,cyclooxygenase enzyme gene polymorphism,and differences in the intestinal microbiota,to provide a reference for the development of individualized dosing regimens for NSAIDs.
