Evaluation of the efficacy of Huoxue Tongluo recipe iontophoresis combined with butyphthalide sequential therapy in hemiplegia patients with cerebral ischemic stroke
10.12173/j.issn.1008-049X.202402052
- VernacularTitle:活血通络方离子导入联合丁苯酞序贯疗法对缺血性脑卒中偏瘫患者疗效的评估
- Author:
Hongli ZHANG
1
;
Peng LI
;
Jie HU
;
Xianglong LYU
Author Information
1. 安徽中医药大学附属滁州中西医结合医院脑病二科(安徽滁州 239000)
- Keywords:
Traditional Chinese medicine iontophoresis;
Butyphthalide sequential therapy;
Cerebral ischemic stroke;
Hemiplegia;
Clinical efficacy;
Safety
- From:
China Pharmacist
2024;27(5):788-795
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the efficacy and safety of the Huoxue Tongluo recipe iontophoresis(HTRI)combined with butylphthalide sequential therapy(BST)in patients with cerebral ischemic stroke(CIS)hemiplegia.Methods 87 patients with CIS hemiplegia treated in Chuzhou Chinese and Western Medicine Hospital affiliated to Anhui University of Chinese Medicine from January 2020 to January 2023 were retrospectively selected as study subjects,and were divided into the BST group(BST treatment)and the combination group(BST in combination with HTRI treatment)according to the treatment regimens.The main observation indicators were total treatment response rate and incidence of adverse reactions after 4 weeks of treatment;the secondary observation indicators were cerebral artery flow velocity[anterior cerebral artery(ACA),middle cerebral artery(MCA)and posterior cerebral artery(PCA)],neurological function[National Institutes of Health Stroke Scale(NIHSS)score,Chinese Stroke Scale(CSS)score]and limb function[Fugl-Meyer Motor Function Scale(FMA)score,Barthel index(BI)score].Results A total of 87 patients were included,including 43 patients in the BST group and 44 patients in the combination group.The total response rate in the combination group was significantly higher than that in the BST group(P<0.05),and no adverse reactions were observed in both groups.Before treatment,there were no significant differences in cerebral artery blood flow velocity,nerve function and limb function between the two groups(P>0.05).After treatment,the flow velocity of ACA,PCA and MCA,and the scores of FMA and BI were significantly higher than those before treatment(P<0.05),while the scores of NIHSS and CSS decreased significantly(P<0.05).Conclusion Compared with BST therapy,HTRI combined with BST has a more significant effect in CIS patients with hemiplegia,with no increase in the incidence of adverse reactions,and has higher safety.
