Advances in applications of multi-omics techniques in study of non-animal alternative new approach methodologies for chemical risk assessment
10.3867/j.issn.1000-3002.2024.10.004
- VernacularTitle:多组学技术在化学物质风险评估非动物替代新途径方法研究中应用进展
- Author:
Yi SUN
1
;
Tao ZUO
;
Ping XU
Author Information
1. 军事医学研究院国家蛋白质科学中心(北京),北京蛋白质组研究中心,医学蛋白质组全国重点实验室,北京 102206;中国医科大学公共卫生学院环境毒理学研究室,辽宁沈阳 110122
- Keywords:
toxico-omics;
in vitro risk assessment;
chemicals;
new approach methodologies
- From:
Chinese Journal of Pharmacology and Toxicology
2024;38(10):752-758
- CountryChina
- Language:Chinese
-
Abstract:
With the explosive growth of knowledge and technologies in biological disciplines repre-sented by omics techniques,which promise broad applications in the field of toxicology.New methods of alternative toxicology to non-animal testing based on transcriptomics are entering the regulatory phase.However,given the limitations of a single omics technique in risk assessment and the fact that the transition from scientific research to regulatory specification has not yet been realized,risk assess-ment will be helped to be accomplished more accurately by integrating multiple new approach method-ologies(NAMs)and different information sources.This review introduces genomics,proteomics,protein post-translational modification genomics and metabonomics,which are currently the focus of attention both at home and abroad,and their prospective applications in chemical risk assessment.
