Progress in integrated approach to testing and assessment(IATA)and its applications
10.3867/j.issn.1000-3002.2024.10.003
- VernacularTitle:整合测试与评估方法(IATA)及其应用进展
- Author:
Hui PENG
1
;
Youjia ZONG
;
Shuangqing PENG
;
Jiabin GUO
Author Information
1. 中国人民解放军疾病预防控制中心,北京 100071;中国医科大学公共卫生学院,辽宁 沈阳 110122
- Keywords:
integrated approaches to testing and assessment;
adverse outcome pathway;
defined approach;
new approach methodologies;
next generation risk assessment
- From:
Chinese Journal of Pharmacology and Toxicology
2024;38(10):742-751
- CountryChina
- Language:Chinese
-
Abstract:
Integrated Approaches to Testing and Assessment(IATA)is a toxicological assessment decision-making method that integrates existing information from various sources,including physical and chemical properties,animal testing,and non-animal testing.Through the evaluation and analysis of a series of iterative strategies,it ultimately obtains risk assessment conclusions,thereby providing a basis for risk management decisions regarding chemical substances.The use of IATA is becoming increasingly prevalent in such areas as ocular irritation and genotoxicity.This paper introduces the conceptual connotation of IATA,sorts out the framework elements and sequential processes,explains the commonly used framework construction methods,shares cases of application in various exposure scenarios,and finally envisions future research directions in order to provide better methodological support for the risk assessment of chemical substances.
