Network pharmacological study on mechanism of modified Wuzi Yanzong pill in alleviating testicular toxicity of Tripterygium wilfordii
- VernacularTitle:加味五子衍宗丸减轻雷公藤睾丸毒性作用机制的网络药理学研究
- Author:
Li-Hui SUN
1
;
Shan-Shan HAN
;
Yan-Lin DAI
;
Shan-Shan XU
;
Jian ZHANG
;
Ya-Ping XING
;
Ying DING
Author Information
- Keywords: tripterygium wilfordii; testicular toxicity; modified Wuzi Yanzong pills; network pharmacology; molecular docking; mechanism of action
- From: Chinese Pharmacological Bulletin 2024;40(12):2385-2391
- CountryChina
- Language:Chinese
- Abstract: Aim To explore the mechanism of modified Wuzi Yanzong pill to reduce testicular toxicity of Tripterygium wilfordii by means of network pharmacolo-gy.Methods The effective chemical composition and target of modified Wuzi Yanzong Pill to reduce testicu-lar toxicity of Tripterygium wilfordii were analyzed by using multiple databases to understand the mechanism of action.Results The first five compounds of modi-fied Wuzi Yanzong pill are quercetin,sucrose,kaempferol,galactose and ellagic acid,respectively.The first five targets were TP53,SRC,EP300,MAPK3,STAT3;KEGG pathway enrichment analysis mainly concentrated in cancer pathway,lipid and atherosclero-sis,hepatitis B,apoptosis,diabetes complications AGE-RAGE signaling pathway,PI3K-Akt signaling pathway and other signaling pathways.Conclusions The ac-tive components of modified Wuzi Yanzong pill can re-duce the testicular toxicity of Tripterygium wilfordii mainly by interfering with TP53,SRC,EP300,MAPK3,STAT3 and other targets,regulating apoptosis,PI3K-Akt signaling pathway,diabetes complications AGE-RAGE signaling pathway,lipid metabolism and other pathways.
