Inflammatory mechanisms and potential drug targets in idiopathic pulmonary fibrosis
- VernacularTitle:特发性肺纤维化的炎症机制与潜在药物靶标
- Author:
Xiao-Jing HAN
1
;
Qi-Qi HAN
;
Feng QIAN
Author Information
- Keywords: idiopathic fibrosis; macrophages; inflammatory re-actions; inflammatory mediators; fibroblasts; potential drug tar-gets
- From: Chinese Pharmacological Bulletin 2024;40(5):828-832
- CountryChina
- Language:Chinese
- Abstract: Idiopathic pulmonary fibrosis(IPF)is a progressive,chronic mesenchymal lung disease,which is difficult to cure.There are many factors that lead to pulmonary fibrosis,such as smoking,external environmental pollution,drugs,viral infec-tions,etc.Alveolar epithelial injury,myofibroblast growth,and collagen deposition are characteristics of idiopathic pulmonary fi-brosis,which in turn leads to dysfunction of functional gas ex-change,respiratory failure,and even death.The pathological mechanism of IPF is unknown and there is a lack of curative drugs,and the morbidity and mortality rate remain high.There-fore,it is urgent to explore the pathogenesis of pulmonary fibro-sis and find new treatment strategies.In this review,we summa-rize the inflammatory mechanisms by which macrophages mediate pulmonary fibrosis,the role of fibroblasts in idiopathic pulmona-ry fibrosis,and the possible potential drug targets.
