Research progress of potassium ion channel Eag1 in tumor
- VernacularTitle:钾离子通道Eag1在肿瘤中的研究进展
- Author:
Xu-Zhao WANG
1
;
Bo-Chang WANG
;
Ya-Fei CHEN
;
Yong ZHAN
;
Wen-Xin LIU
;
Hai-Long AN
Author Information
- Keywords: Eag1; ion channel; physiological characteristics; tumor; regulatory mechanism; modulator
- From: Chinese Pharmacological Bulletin 2024;40(5):823-828
- CountryChina
- Language:Chinese
- Abstract: Eag1(ether-à-go-go-1,also known as Kv10.1,KC-NH1)is a member of the KCNH gene family of voltage-gated potassiumion(K+)channels,which is mainly expressed in the central nervous system as well as in a variety of malignancies and plays an important role in tumor development.The study of the distribution and mechanism of action of Eag1 is of great impor-tance to reveal its physiological function and its association with pathological mechanisms.This paper reviews the current re-search progress on the physiological and pathological properties of Eag1,the relationship between Eag1 and tumor development and the anti-tumor application of Eag1 modulators.
