Role of cathepsin D in cardiovascular events following acute ST-segment elevation myocardial infarction
10.12007/j.issn.0258-4646.2024.10.010
- VernacularTitle:组织蛋白酶D在急性ST段抬高型心肌梗死后心血管事件中的作用
- Author:
Linlin CAI
1
;
Jingru MA
Author Information
1. 沈阳医学院附属第二医院心血管内科,沈阳 110035
- Keywords:
cathepsin D;
acute myocardial infarction;
major cardiovascular adverse event
- From:
Journal of China Medical University
2024;53(10):929-933
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the role of cathepsin D(CTSD)in cardiovascular events after acute ST-segment elevation myocar-dial infarction(STEMI).Methods A total of 96 patients with STEMI admitted to the Department of Cardiovascular Medicine of Second Hospital Affiliated to Shenyang Medical College from November 2022 to July 2023 were selected as the STEMI group.In addition,20 patients with normal coronary angiography hospitalized during the same period were selected as the control group.Coronary blood was collected from both groups,and the relative expression levels of CTSD in the arterial blood were detected and compared using real-time quantitative polymerase chain reaction.The STEMI group was divided into low,medium,and high CTSD groups based on CTSD expression,and major adverse cardiovascular events(MACE)that occurred within 6 months following percutaneous coronary interven-tion(PCI)were monitored.Results Arterial blood CTSD expression(1.31[1.03-1.75])in the STEMI group was higher than that in the control group(1.02[0.67-1.48])(P＜0.05).Statistically significant differences in platelet count as well as troponin T,N-terminal pro-B natriuretic peptide,and high-density lipoprotein cholesterol levels were observed among the three groups(P＜0.05).The incidence of MACE was significantly higher in the low CTSD group(65％)than in the high CTSD group(10％,P＜0.05).Receiver operating cha-racteristic(ROC)curve analysis showed that the area under the ROC curve for predicting MACE within 6 months after PCI in patients with STEMI was 0.765(95％CI:0.658-0.872,P＜0.001).Conclusion Whole blood CTSD expression level is abnormal in STEMI patient.CTSD may be an indicator for predicting the prognosis of STEMI and,therefore,a drug target for preventing and treating STEMI.
