Peripheral blood biomarkers in children and adolescents with depressive disorders
10.3760/cma.j.cn371468-20230914-00109
- VernacularTitle:儿童青少年抑郁障碍的外周血生物标志物
- Author:
Yuxiao ZHAO
1
;
Zhen LIU
;
Wenjing LIU
;
Wenhong CHENG
Author Information
1. 上海交通大学医学院附属精神卫生中心儿童青少年精神科，上海 200030
- Keywords:
Children and adolescents;
Depressive disorder;
Peripheral blood;
Biomarkers
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2024;33(7):665-670
- CountryChina
- Language:Chinese
-
Abstract:
Depressive disorder is a highly prevalent mood disorder among children and adolescents, which can exert profoundly negative impacts on psychosocial development. However, in the current medical system there still lacks objective indicators for the risk assessment, diagnosis and treatment selection of depression in this population. Biomarkers, which serve as objective indicators of physiological states, can offer crucial insights into pathological mechanisms of depressive disorders. This paper provides a comprehensive review of existing research on peripheral blood biomarkers associated with depression in children and adolescents, highlighting the feasibility of their clinical application. Studies indicate that substances in immune, neuroendocrine, neurotrophic, and multi-level omics system in peripheral blood can be significantly linked to the diagnosis and severity of depression in this population. Nevertheless, the predictive role of specific biomarkers necessitates integration with other multimodal data, and replication through studies with large sample size is needed.
