Role of neuroplastin 65 in the central nervous system
10.3760/cma.j.cn371468-20230707-00315
- VernacularTitle:神经黏附分子65在中枢神经系统中的作用
- Author:
Li XU
1
;
Wei ZHANG
;
Zhengliang MA
Author Information
1. 南京大学医学院附属鼓楼医院麻醉科，南京 210008
- Keywords:
Neuroplastin 65;
Central nervous system;
Synaptic plasticity;
Pathophysiology
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2024;33(6):572-576
- CountryChina
- Language:Chinese
-
Abstract:
Neuroplastin 65(NP65) is a glycoprotein class with selective expression in neurons. It is extensively expressed in the synaptic membrane of the central nervous system, and plays a fundamental role in cell adhesion and intercellular communication. In comparison to other cell adhesion molecules, the discovery of NP65 is relatively late and researches about this molecule are still in development. Further exploration and study of the pathophysiological mechanism involved in NP65 are needed. It has been confirmed that NP65 plays a pivotal role in neural activities, including regulation of synaptic formation and maintenance, modulation of synaptic plasticity, facilitation of neuronal development, and contribution to the pathogenesis of various diseases. Thus, NP65 could potentially serve as a crucial target for modulating the growth and operation of the nervous system. This paper provides a comprehensive review of the structure, distribution, function, and involvement in both physiological and pathological processes of NP65. Additionally, the future research direction for NP65 is proposed, with the aim of enhancing our understanding of its function, revealing its mechanism of action in diseases, and providing a theoretical basis for the development of related clinical applications.
