Relationship between serum sLOX-1,CTRP3 levels and re-stenosis after stent intervention in patients with lower ex-tremity arteriosclerosis obliterans
10.3969/j.issn.1009-9905.2024.10.006
- VernacularTitle:下肢动脉硬化闭塞症患者血清sLOX-1、CTRP3水平与支架植入术后再狭窄的关系
- Author:
Li-Ping FU
1
;
Yan-Biao MA
;
Bo MA
;
Qing-He SUN
;
Xu-Chen LÜ
Author Information
1. 沧州市人民医院 介入血管外科(河北 沧州 061000)
- Keywords:
Lower extremity arteriosclerosis obliterans;
Stent intervention;
Postoperative re-stenosis;
Soluble lectin-like oxidized low density lipoprotein receptor-1;
C1q/tumor necrosis fac-tor related protein 3
- From:
Chinese Journal of Current Advances in General Surgery
2024;27(10):784-788
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expression of soluble lectin-like oxidized low den-sity lipoprotein receptor-1(sLOX-1)and C1q/tumor necrosis factor related protein 3(CTRP3)in the serum of patients with lower extremity arteriosclerosis obliterans(ASO)and their relationship with restenosis(ISR)after stent intervention.Methods:From June 2019 to June 2022,106 ASO pa-tients who underwent stent intervention in our hospital were regarded as the study subjects.One year after surgery,they were separated into a non ISR group(n=64)and an ISR group(n=42)based on their onset of ISR.The serum levels of sLOX-1 and CTRP3 were compared between the two groups;multivariate Logistic regression was applied to analyze the influencing factors of ISR after stent intervention in ASO patients;ROC curve was applied to analyze the predictive value of se-rum sLOX-1 and CTRP3 levels for ISR after stent intervention in ASO patients.Results:The se-rum sLOX-1 level in the ISR group was obviously higher than that in the non ISR group(P＜0.05),and the CTRP31 level was obviously lower than that in the non ISR group(P＜0.05).The complete occlusion,and sLOX-1 were independent risk factors for ISR after stent intervention in ASO pa-tients,while CTRP3 was a protective factor for ISR after stent intervention in ASO patients(P＜0.05).The AUC of the combination of serum sLOX-1 and CTRP3 in predicting ISR after stent in-tervention in ASO patients was 0.944,with a sensitivity of 97.62％and a specificity of 79.69％,which was superior to the individual predictions of sLOX-1 and CTRP3(Zcombineddetaction-sLOX-1=2.732,Zcombineddetection-CTRP3=2.143,P=0.006,0.032).Conclusion:After ASO stent intervention,the serum level of sLOX-1 was obviously increased in ISR patients,while the level of CTRP3 was obviously reduced,and the combination of the two fatcors has high predictive value for the occurrence of ISR in ASO patients after stent intervention.
